Sviluppo e rappresentazione digitale di superfici architettoniche complesse per la documentazione e il restauro

Questa ricerca presenta la metodologia che \ue8 stata utilizzata nella rappresentazione delle colonne del Tempio C nel parco archeologico di Selinunte (TP). Tale metodologia \u2013 basata sull'impiego di superfici matematiche ausiliarie e tools di modellazione NURBS \u2013 ha permesso di sviluppare sul piano le superfici mesh di modelli 3D texturizzati realizzati da dati acquisiti con tecniche di rilevamento laser scanning e fotogrammetriche

Ricostruire 2. Architettura - Storia - Rappresentazione

Dall'editoriale di Marco Rosario Nobile: "Il 2014 è stato l’anniversario (bicentenario della nascita) di un grande architetto come Eu- gène Viollet-le-Duc. Per noi, associarsi al ricordo significa anche rilevarne le scomode pre- ferenze (espresse da un ventenne), che farebbero indispettire molti colleghi: «Je le dis peut-être à ma honte, mais je trouve Palladio, Sansovino, Vignole, plus qu’ennuyeux» (lettera da Venezia, estate 1837). Forse questo impietoso giudizio si giustifica con la perfezione delle opere del Cinquecento del centro-nord Italia, nell’assenza di stimoli a rielaborare mentalmente e poi graficamente completamenti, ricostruzioni che comportino qualche difficolta' suppletiva, opere che nella migliore circostanza delineano di per sé la soluzione di un rebus troppo facile, “noioso” per un esperto enigmista. Ricostruire racconta, per esempi di studio, il ridisegno per la storia, ovvero presenta contributi che contemplano il desiderio di prefigurare i casi falliti, quelli sospesi, le vicende in- 5 terrotte o sommerse dai detriti del tempo. Negli ultimi anni, i campi di attività che comportano l’intreccio tra ipotesi storiche e la loro verifica di attendibilità si sono amplificati grazie a strumenti di rappresentazione sempre più sofisticati. Naturalmente si tratta di esercizi, il cui valore non è comunque da derubricare semplicemente alla voce “speculazioni”. Questo gioco ha coinvolto anche storici del Cinquecento di altissima levatura, da Arnaldo Bruschi a Manfredo Tafuri, e con precedenti di questa portata, cercare giustificazioni non serve. Esistono però spiegazioni: si tratta forse di un fascino che gli architetti conoscono bene, quel processo mentale che in passato poteva debordare anche in opere di comple- tamento, mentre, per chi come noi ha assimilato la passione di Ruskin, consente la soprav- vivenza di un angolo per continuare a coltivare le logiche complesse di Viollet-le Duc. Questo numero è stato curato dai dottori Giuseppe Antista e Mirco Cannella"

Editorial - Evolving Trends in Supply Chain Management: Complexity, New Technologies, and Innovative Methodological Approaches

Ministerio de Ciencia e Innovación DPI201680750

Impact of reverse logistics on supply chain performance

Purpose The purpose of this paper is to analyse the impact of reverse logistics on order and inventory variance amplification in a single-echelon supply chain and to propose a new order policy for dampening such amplification. Design/Methodology/Approach A general review of the literature on sustainable operations and on the impact of reverse logistics on SC performance provides the foundation for the study. We use difference equation math approach for modelling and analysing a closed supply chain. A proper design of experiment and data collected from the European Union statistics validate the obtained numerical results. Findings The variability of reverse flow in a closed loop supply chain increases the serviceable inventory variance. However, a proper design of the reverse flow considerably improves the global performance. To this purpose, we propose a new order policy, namely R-APIOBPCS, which explicitly considers the reverse flow of products. Research limitations/Implications The paper presents a math model describing a closed loop supply chain. No empirical analysis is provided. Future researches should evaluate the impact of the proposed R-APIOBPCS on more realistic closed loop supply chain models. Practical implications Our findings may motivate logistics and supply chain managers to implement CLSC when supported by innovative, suitable tools for the proper management of the information and material flow in the chain. Managers should be well acquainted that, by doing so, they not only satisfy National and International legislations but also achieve improvements in logistics performance. Originality/Value We propose a novel replenishment rule that accurately coordinates the upstream and downstream flows in a SC. The proposed order policy can be reasonably considered one of the advocated managerial tools for the proper management of reverse logistics: it allows reducing inventory and limiting the variability of the orders placed to suppliers in supply chain with reverse logistics

Antigen-specific acquired immunity in human brucellosis: implications for diagnosis, prognosis, and vaccine development.

Brucella spp., are Gram negative bacteria that cause disease by growing within monocyte/macrophage lineage cells. Clinical manifestations of brucellosis are immune mediated, not due to bacterial virulence factors. Acquired immunity to brucellosis has been studied through observations of naturally infected hosts (cattle, goats), mouse models (mice), and human infection. Even though Brucella spp. are known for producing mechanisms that evade the immune system, cell-mediated immune responses drive the clinical manifestations of human disease after exposure to Brucella species, as high antibody responses are not associated with protective immunity. The precise mechanisms by which cell-mediated immune responses confer protection or lead to disease manifestations remain undefined. Descriptive studies of immune responses in human brucellosis show that TH(1) (interferon-γ-producing T cells) are associated with dominant immune responses, findings consistent with animal studies. Whether these T cell responses are protective, or determine the different clinical responses associated with brucellosis is unknown, especially with regard to undulant fever manifestations, relapsing disease, or are associated with responses to distinct sets of Brucella spp. antigens are unknown. Few data regarding T cell responses in terms of specific recognition of Brucella spp. protein antigens and peptidic epitopes, either by CD4+ or CD8+ T cells, have been identified in human brucellosis patients. Additionally because current attenuated Brucella vaccines used in animals cause human disease, there is a true need for a recombinant protein subunit vaccine for human brucellosis, as well as for improved diagnostics in terms of prognosis and identification of unusual forms of brucellosis. This review will focus on current understandings of antigen-specific immune responses induced Brucella peptidic epitopes that has promise for yielding new insights into vaccine and diagnostics development, and for understanding pathogenetic mechanisms of human brucellosis

On the bullwhip avoidance phase: the synchronized supply chain

The aim of this paper is to analyse the operational response of a Synchronised Supply Chain (SSC). To do so, first a new mathematical model of a SSC is presented. An exhaustive Latin Square design of experi- ments is adopted in order to perform a boundary variation analysis of the main three parameters of the periodic review smoothing (S,R) order-up-to policy: i.e., lead time, demand smoothing forecasting factor, and proportional controller of the replenishment rule. The model is then evaluated under a variety of performance measures based on internal process benefits and customer benefits. The main results of the analysis are: (I) SSC responds to violent changes in demand by resolving bullwhip effect and by creating stability in inventories under different parameter settings and (II) in a SSC, long production\u2013 distribution lead times could significantly affect customer service level. Both results have important consequences for the design and operation of supply chains

Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound Treatment at 1.5 T: A Retrospective Study on Treatment- and Patient-Related Parameters Obtained From 52 Procedures

Objective: To present a retrospective analysis of patient- and sonication-related parameters of a group of patients treated with a transcranial magnetic resonance imaging (MRI)-guided focused ultrasound (tcMRgFUS) system integrated with a 1.5-T MRI unit. Methods: The data obtained from 59 patients, who underwent the tcMRgFUS procedure from January 2015 to April 2019, were retrospectively reviewed for this study. The following data, among others, were mainly collected: skull density ratio (SDR), skull area (SA), number of available transducer elements (Tx), and estimated focal power at target (FP). For each of the four different treatment stages, we calculated the number of sonication processes (S-n), user-defined sonication power (S-p), effective measured power (S-mp), sonication duration (S-d), user-defined energy (E), effective measured energy (E-m), maximum temperature (T-max), and MR thermometry plane orientation. Furthermore, the time delay between each sonication (S-t) and the total treatment time (T-t) were recorded. Results: Fifty-two patients (40 males and 12 females; age 64.51 +/- SD 11.90 years; range 26-86 years), who underwent unilateral Vim thalamotomy (left = 50, 96.15%; right = 2, 3.85%) for medication-refractory essential tremor (n = 39; 78%) or Parkinson tremor (n = 13; 22%) were considered. A total of 1,068 (95.10%) sonication processes were included in our final analysis (average S-n per treatment: 20.65 +/- 6.18; range 13-41). The energy released onto the planned target was found to decrease with the SDR for all temperature ranges. A positive correlation was observed between the slope of T-max vs. E-m plot and the SDR (R-2 = 0.765; p < 0.001). In addition, the T-max was positively correlated with SDR (R-2 = 0.398; p < 0.005). On the contrary, no significant correlation was found between SDR and SA or Tx. An analysis of the MR thermometry scanning plane indicated that, at our site, the axial and the coronal planes were used (on average) 10.4 (SD +/- 3.8) and 7.7 (SD +/- 3.0) times, respectively, whereas the sagittal plane was used only 2.5 (SD +/- 3.0) times per treatment. Conclusion: Our results confirm the factors that significantly influence the course of a tcMRgFUS procedure even when a 1.5-T MRI scanner is used for procedure guidance. The experience we gained in this study indicates that the SDR remains one of the most significant technical parameters to be considered in a tcMRgFUS procedure. The possibility of prospectively setting the sonication energy according to the presented curves of energy delivery as a function of SDR for each treatment stage could provide a further understanding and a greater awareness of this emerging technology